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Lung India Official publication of Indian Chest Society  
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Year : 1982  |  Volume : 1  |  Issue : 1  |  Page : 29-31

Rifampicin And Ethambutol Intermittent Therapy In The Retreatment Of Failure Cases



Correspondence Address:
V Rangaswamy


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A trial on 50 tuberculosis patients attending the Government Tuberculosis Sanatorium, Tambaram, who had exhausted all the first line drugs form the subject of this report. The tubercle bacilli cultured from these patients were resistant to standard drugs, viz; streptomycin, isoniazid and para amino salicylic acid (PAS). They were, therefore, treated with a combination of rifampicin and ethambutol given initially for one month on a daily basis followed by twice weekly administration of the same two drugs for the remaining 11 months. By three months, 42 patients (84%) had attained sputum negative status. When followed up for another year, 44 (88%) of the 48 quiescent patients maintained bacteriological quiescence of disease, even a year after stopping all anti-tuberculosis drugs. This intermittent reserve regimen for treatment failure patients works out comparatively cheaper in its cost and was found acceptable to patients attending the mobile treatment centres. Adverse reactions due to these two drugs were not a major problem in this study.


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