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Lung India Official publication of Indian Chest Society  
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Year : 1985  |  Volume : 3  |  Issue : 3  |  Page : 115-122

A Study Of Efficacy And Toxicity Of Short-Course Chemotherapy With Ethambutol, Rifampicin, Pyrazinamide And Isoniazid In Pulmonary Tuberculosis



Correspondence Address:
G. R Dubey


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Adult patients with active pulmonary tuberculosis who were given ethambutol (E 20mg/kg) rifampicin (R 10 mg/ kg), pyrazinamide (Z 25mg/ kg), isoniazid (H 5 mg/kg) daily for two months and later twice weekly for four to six months (E 40mg/kg; H 14 mg/kg), were extensively evaluated for response and drug toxicity. Of 126 patients, 110 completed two months and 92 patients finished six or eight months of therapy; at the respective stage 72 (65%) 90, (98%) showed sputum conversion and radiographic improvement was seen in 66% and 95%. Over the next six months, 4 (4.4%) relapsed with INH resistant bacilli. Clinical jaundice was seen in 20 patients after a mean 18 (5-37 days of treatment; in 18, drugs) (R, Z) could be restarted, though bilirubin rose again in three patients. In later months, 15 patients, showed increased bilirubin. Fifteen patients had arthralgia while one developed joint swellings and one skin rash. Ocular toxicity was seen in 13 patients of whom five had temporary subjective or objective changes. In five, persisting diminished visual acuity, field restriction and scotoma were seen and ethambutol was discontinued; two recovered fully in three weeks, one partially but two did not recover. EHRZ regime seems to be effective, acts a little slowly and has some toxicity.


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