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One hundred and thirteen symptomatic victims of methyl isocyanate (MIC) toxicity were investigated by peforming maximal expiratory flow volume measurement sequentially for 18 months. Expiratory flows remained low and inspiratory flows declined. Abnormalities of the flow volume loop included saw tooth (12.3%). doming (16.5%), hesitation (25.8%) in inspiration and doming (30%) and concavity (53.6%) during expiration. The changes persisted despite improved spirometric values.