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Serum protein bound fucose and ESR levels were estimated in 20 healthy control subjects, and 70 patients with pulmonary tuberculosis. The mean serum fucose value in controls was 10.13 ± 1.97 mg%. The fucose levels were significantly higher in patients with cavitary disease and those with positive sputum. Serial comparison of mean serum fucose and ESR levels, before and during treatment, showed a trend towards fall in both; the fall in fucose being more steady and more complete at three months.