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Lung India Official publication of Indian Chest Society  
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Year : 1990  |  Volume : 8  |  Issue : 1  |  Page : 19-21

Comparison Of Allergic Markers And Airway Hyperreactivity In Bronchial Asthma And Chronic Bronchitis



Correspondence Address:
R. U Rupwate


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Spirometric function, histamine PC20, blood and sputum eosinophilia, cutaneous atopy and IgE levels were compared in a selected group of 25 bronchial asthma and 16 chronic bronchitis subjects. The former were younger nonsmokers and 44% showed a family history of allergy; for clinical symptoms both groups had similar duration (5.9 to 6.2 years). The asthmatics had higher FEV1 and FEV1 improvement after bronchodilator (p<0.05). While there were no differences for blood eosinophil levels, for sputum eosinophilia the values were 2.12 ±1.8 and 0.8 ±1.0 respectively (p<0.05). Histamine PC20 concentrations were 0.13 ±0.21 and 0.33 ±0.26 mg/ml for asthma and bronchitis subjects (p<0.05). For cutaneous allergy score (4.9 ±2.5 and 0.9 ±0.9) and IgE (852 ±467) and 379 ±237 IU) the differences were significant. Thus, between two groups of obstructive airway subjects, these criteria may serve to identify difficult cases.


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