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Lung India Official publication of Indian Chest Society  
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Year : 1998  |  Volume : 16  |  Issue : 4  |  Page : 155-158

Bronchogenic Carcinoma In Patients Below Age 40 Years And The Response To Radiotherapy With Or Without CMF (Cyclophosphamide, Methotrexate, Fluorouracil) Regime.

Correspondence Address:
V. K Arora

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Source of Support: None, Conflict of Interest: None

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Of the 200 patients who had histopathologically confirmed bronchogenic carcinoma during the period January 1990 to March 1996, 24 patients (12%) were found to be below 40 years of age in a tertiary Institute. Of the 24 cases, ten had adenocarcinoma, nine had squamous cell carcinoma, four had poorly differentiated carcinoma and one had large cell carcinoma. These 24 patients were randomly divided into two groups to evaluate the role of radiotherapy alone or radiotherapy with CMF (cyclophosphamide, methotrexate and fluorouracil) regime in the treatment of bronchogenic carcinoma in patients below 40 years. None of the patients in both groups had shown complete response to treatment on follow up. The mean duration of survival of the study subjects was seven months. Bronchogenic carcinoma in young adults, therefore, appears to be aggressive in nature and their response to treatment with radiotherapy and CMF regimen is poor.

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