Home | About us | Editorial Board | Search | Ahead of print | Current Issue | Archives | Instructions | Online submissionContact Us   |  Subscribe   |  Advertise   |  Login  Page layout
Wide layoutNarrow layoutFull screen layout
Lung India Official publication of Indian Chest Society  
  Users Online: 928   Home Print this page  Email this page Small font size Default font size Increase font size

  Table of Contents    
ORIGINAL ARTICLE
Year : 2021  |  Volume : 38  |  Issue : 1  |  Page : 23-30  

A survey of medical thoracoscopy practices in India


1 Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India
2 Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi; Department of Pulmonary Medicine, Christian Medical College, Vellore, Tamil Nadu, India

Date of Web Publication31-Dec-2020

Correspondence Address:
Karan Madan
Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi - 110 029
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/lungindia.lungindia_295_20

Rights and Permissions
   Abstract 


Background: Medical thoracoscopy (MT) is a useful diagnostic and therapeutic procedure for a variety of pleural conditions. There is a lack of literature on prevalent practices of MT in India. Aims and Objectives: The objective of the study was to study the prevalent practices of MT in India. Materials and Methods: A structured online survey on various aspects of thoracoscopy was designed on the “Google Forms” web software. Results: One hundred and eight responses were received, of which 100 respondents performed MT. The majority were pulmonologists, and most had started performing thoracoscopy within the last 5 years. Rigid thoracoscope was the most commonly used instrument. The common indications of procedure included undiagnosed pleural effusion, talc pleurodesis, and adhesiolysis. Local anesthesia with conscious sedation was the preferred anesthetic modality. Midazolam, along with fentanyl, was the most widely used sedation combination. 2% lignocaine was the most commonly used concentration for local infiltrative anesthesia. Nearly two-thirds of the respondents reported having encountered any complication of thoracoscopy. Significant reported complications included empyema, incision/port-site infection, re-expansion pulmonary edema, and procedure-related mortality. Conclusion: MT is a rapidly evolving interventional pulmonology procedure in India. There is, however, a significant variation in practice and variable adherence to available international guidelines on thoracoscopy. Formal training programs within India and national guidelines for pleuroscopy considering the local resources are required to improve the safety and yield of this useful modality.

Keywords: Lung cancer, pleura, pleural effusion, pneumothorax, thoracoscopy


How to cite this article:
Madan K, Tiwari P, Thankgakunam B, Mittal S, Hadda V, Mohan A, Guleria R. A survey of medical thoracoscopy practices in India. Lung India 2021;38:23-30

How to cite this URL:
Madan K, Tiwari P, Thankgakunam B, Mittal S, Hadda V, Mohan A, Guleria R. A survey of medical thoracoscopy practices in India. Lung India [serial online] 2021 [cited 2021 Jan 22];38:23-30. Available from: https://www.lungindia.com/text.asp?2021/38/1/23/306010




   Introduction Top


Undiagnosed pleural effusion is a common clinical scenario that pulmonologists encounter in clinical practice. A pleural biopsy is usually the next line of investigation for a pleural effusion that remains undiagnosed despite diagnostic thoracentesis. Medical thoracoscopy (MT)/pleuroscopy allows one to obtain pleural biopsy under direct visualization using a variety of available (rigid or flexi-rigid) instruments.[1] Apart from pleural biopsy, other pleural interventions are also feasible during pleuroscopy. MT/pleuroscopy is a rapidly growing facet of interventional pulmonology.[2] Pulmonologists are increasingly adopting this modality for a variety of diagnostic and therapeutic indications. Few international guidelines are available on the technical performance of the procedure.[3] Limited literature is available regarding the prevalent practices of pleuroscopy in India.

MT practices vary according to individual preference and availability of resources. We designed this survey to study the prevalent practices of MT in India.


   Materials and Methods Top


This survey on the practices of MT was a collaborative online survey conducted by the Department of Pulmonary, Critical care, and Sleep Medicine at the All India Institute of Medical Sciences, New Delhi, India, and the Department of Pulmonary Medicine at the Christian Medical College, Vellore, India. The survey consisted of 84 questions, divided into four sections. The online study was undertaken using the “Google Forms” interface in English. Google Forms is a free online tool for the administration of personalized surveys and is commonly utilized in medical research. The responses can be automatically retrieved to a spreadsheet and analyzed.[4],[5]

The structured questionnaire was divided into various sections. It consisted of multiple questions on general information, respondent expertise, mode of learning thoracoscopy, indications, patient preparation, monitoring, periprocedural sedation, local anesthesia, and postprocedural complications of pleuroscopy. A preliminary questionnaire was prepared and circulated among authors for discussion. Subsequently, the survey was mock filled and reviewed, and questions were refined based on individual inputs and discussion. The final questionnaire link was E-mailed to pulmonologists across the country using E-mail lists from major national bodies, i.e., the Indian Association for Bronchology, the Indian Chest Society, and the National College of Chest Physicians of India. Furthermore, personal E-mail lists of authors identified potential respondents. We sent E-mails, and a reminder E-mail was sent 1 month later. The survey link was kept open for responses for the next 6 months. Participation was entirely voluntary and without any financial incentive. For statistical analysis, replies were downloaded as excel spreadsheets and analyzed. Responses from those performing MT were included in the study. Descriptive statistical analysis was performed using STATA statistical analysis package (version 11.2), StataCorp LLC, Texas, USA. Categorical variables were presented as number (percentages) and continuous variables as mean (standard deviation) or median (interquartile range [IQR]).P < 0.05 was considered statistically significant.


   Results Top


We received 108 responses, of which 100 responded that they were performing MT. The responses from these 100 participants were included in the final analysis.

Baseline characteristics and indications for the procedure

The baseline demographic characteristics are summarized in [Table 1]. The mean age of the respondents was 40.5 (±8.46) years, and 95% were males. Pulmonologists comprised the majority (95%), 4 (4%) were physicians, and one of the respondents (1%) was a thoracic surgeon. Almost two-thirds of the respondents (67%) had begun performing the procedure in the last 5 years. The median number of procedures performed in the previous year was 20 (IQR: 3–90). Of the respondents performing thoracoscopy, the majority practiced in private setup (56%); 28% were teaching faculties in medical colleges, 4% were super-specialty trainees, whereas 2% were postgraduate trainees. Thirty-three percent had learned the procedure by working under someone performing thoracoscopy, 17% had undertaken formal training programs outside India, 15% had learned in a training workshop, whereas 13% were self-taught. Only 19% of the respondents had learned thoracoscopy in a formal training program in India.
Table 1: Baseline characteristics of the survey respondents

Click here to view


Rigid thoracoscope was the most commonly used instrument (42.0%), whereas the flexi-rigid thoracoscope was used by 29.0%. Almost a quarter (26%) of the respondents were utilizing both rigid and flexi-rigid thoracoscopes. Three percent of the respondents used a flexible bronchoscope for thoracoscopic examination. The rigid thoracoscope with a 10-mm diameter (with a 5-mm working channel) was the most commonly used (61.6%) instrument. 8.3% of the respondents were using the mini-thoracoscope. Operation theaters (48%) and bronchoscopy rooms (45.0%) were the standard locations for performing MT. The median number of assistants involved during thoracoscopy was 3 (IQR: 1–5). A video recording facility for the procedure was available in 84% of facilities. Surgical backup for management of potential complications was available with 81% of the respondents, and 68% had availability of separate recovery room for postprocedure monitoring. There was limited availability of instruments such as cryoprobes (18%) and electrocautery-diathermy (24%) in the thoracoscopy units.

The most common indications for thoracoscopy [Table 1] were evaluation of an undiagnosed pleural effusion (99.0%), performing talc pleurodesis (71.0%), and adhesiolysis (74.0%). Others included visceral pleural biopsy (17.0%), treatment of pneumothorax (15.0%), pinch lung biopsy (11.0%), pericardial window (1%), and sympathectomy (4%). All proceduralists used standard personal protective equipment during the procedure.

Patient preparation, sedation, and monitoring

Written informed consent was obtained by most (97%) of the respondents before thoracoscopy. Less than half (45%) of the proceduralists provided an information sheet to the patients while scheduling the procedure. The majority of the respondents tend to obtain hemoglobin levels (91%), platelet counts (96%), and coagulation studies (89%) before the procedure. Blood glucose and renal function parameters were obtained by 70% and 79% of the respondents, respectively. The vast majority (91%) considered a recent chest radiograph or computed tomography (CT) scan of the thorax as an essential prerequisite for performing thoracoscopy. The patient preparation and monitoring details are shown in [Table 2].
Table 2: Preprocedure investigations and patient preparation before thoracoscopy

Click here to view


Almost all respondents (97%) routinely fasted the patients before thoracoscopy. Most of the respondents required patients to fast for >4 h, with the majority (64.3%) asking patients to fast for 4–6 h and 31.6% fasting patients for >6 h [Table 3]. 61.7% would consider discontinuing both aspirin and clopidogrel before thoracoscopy. 28.3% stopped only clopidogrel, whereas 4% allowed patients to continue dual antiplatelets. Most of the respondents required the patients to get admitted to the hospital 1 day prior (56%) or on the day (28.3%) of the procedure. Seventy-seven percent of the respondents considered CT thorax as a mandatory prerequisite before thoracoscopy. Local anesthesia with conscious sedation (76%) was the most commonly preferred anesthetic modality; 18% of the respondents preferred general anesthesia for the procedure. During the procedure, 61.2% administered continuous oxygen supplementation, whereas 34.7% administered oxygen only in case of desaturation during the procedure. Prophylactic low-molecular-weight heparin administration for patients at a high risk of venous thromboembolism was practiced regularly by only 32% of the respondents. These details are summarized in [Table 3].
Table 3: Patient preparation and monitoring details during thoracoscopy

Click here to view


The sedative and anesthesia practices reported in the survey are shown in [Table 4]. A combination of agents was preferred for sedation by the majority (65.7%). Midazolam, along with fentanyl, was preferred by 54.5%, whereas 18.2% administered only midazolam. Only 7.1% routinely performed thoracoscopy under general anesthesia. 44.2% of the respondents reported the availability of both naloxone and flumazenil in the procedure area. None of the two reversal agents were available in 35.8% of the cases. Anesthesiologists administered sedation for 50% of the respondents, whereas bronchoscopy nurses administered sedation in 24.5%. 2% lignocaine was used most commonly (84.5%) for local infiltrative anesthesia. 36.5% did not monitor or document the total dose of lignocaine. 7.2% of the operators had encountered signs of possible lignocaine toxicity after thoracoscopy.
Table 4: Sedation and local anesthesia during thoracoscopy

Click here to view


Procedure performance and technical aspects

The procedure performance characteristics are summarized in [Table 5]. Thirty-four percent of the respondents preferred IV access on the hand on the same side as that of thoracoscopy. Thirty-eight percent preferred IV access on the contralateral side, and 26% did not have any specific preference.
Table 5: Procedural and technical aspects of thoracoscopy

Click here to view


Nearly half (55.1%) performed a chest ultrasound just before the procedure. Pneumothorax induction before thoracoscopy was routinely performed by only 20% of the individuals. Povidone-iodine was the most preferred agent (86.9%) for skin preparation at the incision site. The intercostal nerve block was only practiced by 21.2% of the respondents, whereas the vast majority (78.9%) performed the procedure under local anesthesia only. The commonly used accessories for pleural insertion were metallic cannula with blunt conical tip trocar (44.9%) and plastic trocar with a cannula (40.8%). The majority of the respondents (79%) used approximately 1–2 cm size incision for trocar introduction. Triangle of safety was the preferred thoracoscopy port creation site in the majority (54.6%). However, 43.4% of the respondents made this decision based on preprocedure ultrasound findings. Only 8.2% of the respondents utilized a second entry port during MT. Most of the respondents (82.8%) routinely obtained a chest radiograph following thoracoscopy.

Postthoracoscopy, the chest drain was removed by most of the respondents after lung expansion, on the same day (23.2%), or the next day (59.6%). In patients with nonexpanding lung following thoracoscopy, 67% discharged the patients with intercostal tube and bag. 11.3% would consider the insertion of an indwelling pleural catheter. Most of the respondents obtained 4–8 pleural biopsy pieces; all respondents sent samples for histopathology and relevant cultures, including for tuberculosis, as indicated. 18.2% of the respondents performed pleural cryobiopsy. Most of the respondents tend to discharge patients by the next day (67.4%), and 9.2% discharge the patients on the same day.

Complications

Around two-thirds (68.8%) of the respondents reported that they had experienced some intraprocedural or procedure-related complications. Infective complications were most common. Empyema and incision/port-site infections were reported by 21.5% and in 7.7% of the respondents, respectively. Other reported complications included persistent air leak >48 h (16.9%), bleeding complications (either from biopsy or port site) (16.9%), failure of lung expansion (13.8%), and re-expansion pulmonary edema (9.2%). 6.2% reported having encountered severe cardiovascular complications (such as acute coronary syndrome and arrhythmias) following thoracoscopy. 7.7% of the respondents reported any procedure-related mortality. [Table 6] describes the details of thoracoscopy related complications reported in this survey.
Table 6: Complications of thoracoscopy encountered by respondents

Click here to view



   Discussion Top


We report the results of a comprehensive national survey on the prevalent practices of MT in India. This survey is the first survey on thoracoscopy practices in India, and the survey questionnaire is one of the most comprehensive, considering the few international studies also undertaken in this regard.

The findings of the survey highlight many vital aspects of thoracoscopy practice in India. There is an urgent need for formal thoracoscopy training programs in the country. Only a limited number of respondents received formal training in performing the procedure. There is greater use of the rigid thoracoscope in India, and these findings are similar to those reported in the USA and UK.[6],[7],[8] The diagnostic yield of either the rigid or the flexi-rigid thoracoscope is identical.[1],[9] However, pain is likely to be reduced with the use of a flexi-rigid thoracoscope.[1] Interestingly, 26% of the respondents used both scopes. This likely reflects the degree of expertise with the proceduralist, wherein a particular scope may be used depending on the individual scenario. This is also reflected by the fact that a relatively large number of respondents reported the performance of advanced pleural procedures and not just limited to parietal pleural biopsy. This likely indicates that the survey responses likely report the characteristics of experienced operators.

Thoracic societies have published guidelines on the technical considerations of MT.[3] The findings of the survey also highlight differences in prevalent practices as compared with the available guidelines. Checklists have been demonstrated to decrease medical errors and improve quality and patient outcomes. In a recent survey, 75% of the respondents performing thoracoscopy used checklists; however, we did not ask this question in our survey.[10] Patient information sheets are recommended for a better understanding of the procedure for the patients; however, in the survey, only 45% of the respondents regularly provided written patient information sheets. An important observation was that only 32% of the respondents regularly administered prophylactic low-molecular-weight heparin to patients at high risk of venous thromboembolism. Preprocedure nonsteroidal anti-inflammatory drug administration is recommended as an aid to analgesia in local anesthetic thoracoscopy; however, this was practiced routinely only by 8% of the respondents. The use of thoracic ultrasound to decide the entry port is preferable best practice, but this was not routine in the survey. Another important observation was that only 9.3% of the respondents used lignocaine in recommended concentrations (0.5%–1%), and most (84.5%) used 2% lignocaine for local anesthesia. This is important because a higher dose of lignocaine may be associated with adverse consequences.[11] An upper limit of 3 mg/kg for infiltration of lignocaine has been suggested to avoid toxicity; however, more than one-third of the respondents did not document cumulative lignocaine dose. A relatively large proportion used prophylactic antibiotics as a routine. However, this practice has not been found to reduce the risk of infectious complications following thoracoscopy.[12] Pleural cryobiopsy is another commonly utilized method in pleuroscopy, which is safe, albeit without a significant increase in diagnostic yield.[13],[14] The use of pleural cryobiopsy in our survey was less as compared to another survey of flexi-rigid thoracoscopy use.[6] In our survey, only 9.2% of the respondents discharged patients on the same day postprocedure. This is different from practice elsewhere, wherein thoracoscopy is largely performed as a day-care procedure.[6],[8]

Our study had certain limitations. Despite using various databases and personal contacts, we may have missed contacting potential respondents. Electronic surveying methodology could potentially have caused the exclusion of some respondents and could introduce a selection bias. We did not cover certain areas such as utilization of thoracoscopy checklist, thoracoscope cleaning and storage practices, modification of anticoagulation before the procedure, and management of complications. However, a more elaborate questionnaire might have reduced response rates or increased frequency of incomplete responses.


   Conclusion Top


MT is a rapidly evolving interventional pulmonology procedure in India, with an increasing number of centers and pulmonologists beginning to perform the procedure over the past few years. There is a need to enhance the availability of formal thoracoscopy training programs in India. National guidelines on MT are required to standardize the technical and procedural aspects of thoracoscopy.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Bansal S, Mittal S, Tiwari P, Jain D, Arava S, Hadda V, et al. Rigid mini-thoracoscopy versus semirigid thoracoscopy in undiagnosed exudative pleural effusion: The MINT randomized controlled trial. J Bronchology Interv Pulmonol 2020;27:163-71. doi: 10.1097/LBR.0000000000000620.  Back to cited text no. 1
    
2.
Nattusamy L, Madan K, Mohan A, Hadda V, Jain D, Madan NK, et al. Utility of semi-rigid thoracoscopy in undiagnosed exudative pleural effusion. Lung India 2015;32:119-26.  Back to cited text no. 2
[PUBMED]  [Full text]  
3.
Rahman NM, Ali NJ, Brown G, Chapman SJ, Davies RJ, Downer NJ, et al. Local anaesthetic thoracoscopy: British Thoracic Society Pleural Disease Guideline 2010. Thorax 2010;65 Suppl 2:ii54-60.  Back to cited text no. 3
    
4.
Lee W, Shin SY, Seo DW, Sohn CH, Ryu JM, Lee JH, et al. Rapid collection of opinions from healthcare professionals in multiple institutions using short message service and google forms. Healthc Inform Res 2017;23:135-8.  Back to cited text no. 4
    
5.
Madan K, Mohan A, Agarwal R, Hadda V, Khilnani GC, Guleria R. A survey of flexible bronchoscopy practices in India: The Indian bronchoscopy survey (2017). Lung India 2018;35:98-107.  Back to cited text no. 5
[PUBMED]  [Full text]  
6.
Raman T, Mcclelland S, Bartter T, Meena N. Current practice in management of exudative pleural effusions – A survey of American Association of Bronchology and Interventional Pulmonology (AABIP). J Thorac Dis 2018;10:3874-8.  Back to cited text no. 6
    
7.
Hallifax RJ, Corcoran JP, Psallidas I, Rahman NM. Medical thoracoscopy: Survey of current practice-How successful are medical thoracoscopists at predicting malignancy? Respirology 2016;21:958-60.  Back to cited text no. 7
    
8.
de Fonseka D, Bhatnagar R, Maskell NA. Local anaesthetic (medical) thoracoscopy services in the UK. Respiration 2018;96:560-3.  Back to cited text no. 8
    
9.
Dhooria S, Singh N, Aggarwal AN, Gupta D, Agarwal R. A randomized trial comparing the diagnostic yield of rigid and semirigid thoracoscopy in undiagnosed pleural effusions. Respir Care 2014;59:756-64.  Back to cited text no. 9
    
10.
Duncan T, Clarke S, Hoyle J. P188 survey of use of safety checklists and standardisation of practice in thoracoscopy centres in the UK. Thorax 2015;70 Suppl 3:A171.  Back to cited text no. 10
    
11.
Mittal S, Mohan A, Madan K. Ventricular tachycardia and cardiovascular collapse following flexible bronchoscopy: Lidocaine cardiotoxicity. J Bronchology Interv Pulmonol 2018;25:e24-6.  Back to cited text no. 11
    
12.
Dhooria S, Sehgal IS, Prasad KT, Bal A, Aggarwal AN, Behera D, et al. A randomized trial of antimicrobial prophylaxis in patients undergoing medical thoracoscopy (APT). Respiration 2017;94:207-15.  Back to cited text no. 12
    
13.
Dhooria S, Bal A, Sehgal IS, Prasad KT, Muthu V, Aggarwal AN, et al. Pleural cryobiopsy versus flexible forceps biopsy in subjects with undiagnosed exudative pleural effusions undergoing semirigid thoracoscopy: A crossover randomized trial (COFFEE Trial). Respiration 2019;98:133-41.  Back to cited text no. 13
    
14.
Shafiq M, Sethi J, Ali MS, Ghori UK, Saghaie T, Folch E. Pleural cryobiopsy: A systematic review and meta-analysis. Chest 2020;157:223-30.  Back to cited text no. 14
    



 
 
    Tables

  [Table 1], [Table 2], [Table 3], [Table 4], [Table 5], [Table 6]



 

Top
  
 
  Search
 
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    Abstract
   Introduction
    Materials and Me...
   Results
   Discussion
   Conclusion
    References
    Article Tables

 Article Access Statistics
    Viewed308    
    Printed2    
    Emailed0    
    PDF Downloaded87    
    Comments [Add]    

Recommend this journal