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Year : 2021  |  Volume : 38  |  Issue : 2  |  Page : 204-205  

Profile of sleep-disordered breathing in ILD: Could be better with study design?

Department of Pulmonary Medicine, AIIMS, Patna, Bihar, India

Date of Submission20-Oct-2020
Date of Acceptance26-Nov-2020
Date of Web Publication02-Mar-2021

Correspondence Address:
Deependra Kumar Rai
Department of Pulmonary Medicine, AIIMS, Patna, Bihar
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/lungindia.lungindia_838_20

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How to cite this article:
Rai DK. Profile of sleep-disordered breathing in ILD: Could be better with study design?. Lung India 2021;38:204-5

How to cite this URL:
Rai DK. Profile of sleep-disordered breathing in ILD: Could be better with study design?. Lung India [serial online] 2021 [cited 2021 Apr 11];38:204-5. Available from: https://www.lungindia.com/text.asp?2021/38/2/204/310561


I read the manuscript with great interest and congratulate the authors for well-written manuscript.[1] Manuscript was mentioned as prospective observational study but, in this, design of study needs to follow the same group of cohorts for some period to know the association between some factors with outcome variable. This study seems to be simple observational cross-sectional study.[2] Inclusion criteria and exclusion was not defined. What could be the region for inclusion of defined period and total study subject of 100. Was it total 100 consecutive patients diagnosed as Interstitial lung disease (ILD) in given period? Or there were any exclusion criteria like patient who already diagnosed as ILD on treatment or patient require oxygen or who denied for sleep study etc.

Nocturnal Oxygen desaturation (NOD) was not defined. Nocturnal desaturation occurs frequently in ILDs especially in idiopathic pulmonary fibrosis.[3],[4] Significant nocturnal desaturation considered when >10% of sleep with oxygen saturation (SpO2) <90%. Desaturation index was defined as the number of desaturation events >4%/h. Although 10% or more of total sleep time with SpO2 <90% has been defined as “significant” nocturnal hypoxemia and it has prognostic value in ILD, specific thresholds have not been established.[5] If this threshold used to define NOD, it should be clearly mentioned in materials and methods.

Author mentioned that the mean forced vital capacity (FVC) in the study group was 53.67% predicted, 50% predicted in patients with obstructive sleep apnea (OSA), 45.56% predicted in patient having NOD without OSA, and 57.87% predicted in patients with no sleep-disordered breathing (SDB). The difference was said statistically significant with P = 0.48 (<0.5). No comment on statistical method performed for correlation and how can P = 0.48 become significant. Mean FVC was found lowest in group NOD without OSA (45.56%), Is it means that restriction is more due to Nocturnal desaturation than OSA? It is very important to know the range of data but did not find standard deviation or quartile deviation for continuous variable or categorical variable. P value was wrongly interoperated not only for FVC but also for mean 6-min walking distance, PaO2, and pulmonary arterial systolic pressure.

ILD is not only associated with OSA as comorbidities but other such as diabetes, hypertension, obesity, and chronic obstructive pulmonary disease. No comment on that as it could influence the all outcome variable measured.

The study was performed to assess prevalence and profile of SDB and OSA. Sleep disorder of breathing include 4 disease central sleep apnea syndromes, OSA disorders, sleep-related hypoventilation disorders, sleep-related hypoxemia disorder but no comment found on hypoventilation and central sleep apnea in whole manuscript.

In last, the study was concluded as SDB in ILD is associated with a significant impact on the cardinal determinants of functional capacity, lung function, and quality of life. However, primary objective of study was prevalence of SDB in ILD and also quality of life was not assessed.

Thanking you and authors!

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

   References Top

Utpat K, Gupta A, Desai U, Joshi JM, Bharmal RN. Prevalence and profile of sleep-disordered breathing and obstructive sleep apnea in patients with interstitial lung disease at the pulmonary medicine department of a tertiary care hospital in Mumbai. Lung India 2020;37:415-20.  Back to cited text no. 1
[PUBMED]  [Full text]  
Song JW, Chung KC. Observational studies: Cohort and case-control studies. Plast Reconstr Surg 2010;126:2234-42.  Back to cited text no. 2
Lancaster LH, Mason WR, Parnell JA, Rice TW, Loyd JE, Milstone AP, et al. Obstructive sleep apnea is common in idiopathic pulmonary fibrosis. Chest 2009;136:772-8.  Back to cited text no. 3
Kolilekas L, Manali E, Vlami KA, Lyberopoulos P, Triantafillidou C, Kagouridis K, et al. Sleep oxygen desaturation predicts survival in idiopathic pulmonary fibrosis. J Clin Sleep Med 2013;9:593-601.  Back to cited text no. 4
Corte TJ, Wort SJ, Talbot S, Macdonald PM, Hansel DM, Polkey M, et al. Elevated nocturnal desaturation index predicts mortality in interstitial lung disease. Sarcoidosis Vasc Diffuse Lung Dis 2012;29:41-50.  Back to cited text no. 5


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