Lung India

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 38  |  Issue : 3  |  Page : 216--222

Challenges, experiences, and postoperative outcomes in setting up first successful lung transplant unit in India


Vijil Rahulan1, Unmil Shah1, Pavan Yadav1, Srinivasa Ravipathy1, Apar Jindal1, S Suresh1, HS Sandeepa2, Pradeep Kumar1, Anoop Mohandas1, Sharanya Kumar1, Shivaprakash Shivanna1, Santosh Kori3, Prabhat Dutta1, Prem Anand1, BN Mahesh1, N Madhusudana3, BV Bhaskar3, G Balasubramani1, Sandeep Attawar1 
1 Institute of Heart and Lung Transplant, Gleneagles Global Health City, Chennai, Tamil Nadu, India
2 Department of Pulmonology, BGS Global Hospital, Bengaluru, Karnataka, India
3 Department of CTVS, BGS Global Hospital, Bengaluru, Karnataka, India

Correspondence Address:
Dr. Vijil Rahulan
Institute of Heart and Lung Transplant, Gleneagles Global Health City, Chennai, Tamil Nadu
India

Background: Lung transplantation (LT) has emerged as a definitive cure for a plethora of end-stage lung diseases (ESLDs). With improvements in immune-suppression protocols, the posttransplantation survival rates have gone up. Aim: The study reported the initial experience of the India's single largest lung transplant program on clinicopathological profile, procedures, challenges encountered, and outcomes. Settings and Design: A retrospective analysis was done from data available at three centers of Institute of Heart and Lung Transplant, Gleneagles Global Hospitals across Chennai, Bengaluru, and Mumbai. Materials and Methods: A total of 132 patients underwent lung (single or bilateral) or combined heart and lung transplant between April 2017 and March 2020. All the participants had 30 days' follow-up. Postoperative complications, graft rejection, and 30-day mortality were reported. Kaplan–Meier survival analysis and logistic regression analysis were performed. Statistical Analysis Used: Kaplan–Meier survival and binary logistic regression was performed. Results: Interstitial lung diseases, 65.91%, were the most common diagnosis. Bilateral LT (81.3%) was the most common type of LT performed. Grade III primary graft dysfunction was observed in 16 (12.1%). Distal airway stenosis (21.97%) was the most common complication followed by anastomotic stenosis (14.30%). Gram-negative bacterial sepsis (52%) was the leading cause of death. Cumulative probability of survival at 1 month was 0.85 (95% confidence interval [CI] 0.80–0.92), and at 1 year, it was 0.78 (95% CI, 0.72–0.86). Conclusion: This study establishes the fact that despite multiple challenges, LT is a viable option for selected patients with ESLDs in India and should encourage early referrals to a transplant center.


How to cite this article:
Rahulan V, Shah U, Yadav P, Ravipathy S, Jindal A, Suresh S, Sandeepa H S, Kumar P, Mohandas A, Kumar S, Shivanna S, Kori S, Dutta P, Anand P, Mahesh B N, Madhusudana N, Bhaskar B V, Balasubramani G, Attawar S. Challenges, experiences, and postoperative outcomes in setting up first successful lung transplant unit in India.Lung India 2021;38:216-222


How to cite this URL:
Rahulan V, Shah U, Yadav P, Ravipathy S, Jindal A, Suresh S, Sandeepa H S, Kumar P, Mohandas A, Kumar S, Shivanna S, Kori S, Dutta P, Anand P, Mahesh B N, Madhusudana N, Bhaskar B V, Balasubramani G, Attawar S. Challenges, experiences, and postoperative outcomes in setting up first successful lung transplant unit in India. Lung India [serial online] 2021 [cited 2021 Jun 16 ];38:216-222
Available from: https://www.lungindia.com/article.asp?issn=0970-2113;year=2021;volume=38;issue=3;spage=216;epage=222;aulast=Rahulan;type=0