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2006| January-March | Volume 23 | Issue 1
January 30, 2009
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Chronic obstructive pulmonary disease and peripheral neuropathy
Prem Prakash Gupta, Dipti Agarwal
January-March 2006, 23(1):25-33
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death world-wide and a further increase in the prevalence as well as mortality of the disease is predicted for coming decades. There is now an increased appreciation for the need to build awareness regarding COPD and to help the thousands of people who suffer from this disease and die prematurely from COPD or its associated complication(s). Peripheral neuropathy in COPD has received scanty attention despite the fact that very often clinicians come across COPD patients having clinical features suggestive of peripheral neuropathy. Electrophysiological tests like nerve conduction studies are required to distinguish between axonal and demyelinating type of disorder that cannot be analyzed by clinical examination alone. However, various studies addressing peripheral neuropathy in COPD carried out so far have included patients with COPD having markedly varying baseline characteristics like severe hypoxemia, elderly patients, those with long duration of illness, etc. that are not uniform across the studies and make it difficult to interpret the results to a consistent conclusion. Almost one-third of COPD patients have clinical evidence of peripheral neuropathy and two-thirds have electrophysiological abnormalities. Some patients with no clinical indication of peripheral neuropathy do have electrophysiological deficit suggestive of peripheral neuropathy. The more frequent presentation consists of a polyneuropathy that is subclinical or with predominantly sensory signs, and the neurophysiological and pathological features of predominantly axonal neuropathy. The presumed etiopathogenic factors are multiple: chronic hypoxia, tobacco smoke, alcoholism, malnutrition and adverse effects of certain drugs.
Pulmonary alveolar microlithiasis
K Gowrinath, Arun R Warrier
January-March 2006, 23(1):42-44
Role of sputum cultures in diagnosis of respiratory tract infections
January-March 2006, 23(1):20-24
Breathlessness & respiratory diseases
R Vijai Kumar
January-March 2006, 23(1):34-38
Ventilator dependence: Role of nutrition and airway clearance therapy
G Sindhwani, J Rawat
January-March 2006, 23(1):39-41
Eosinophilic bronchitis: Clearing confusion
January-March 2006, 23(1):1-2
Emotional aspects of bronchial asthma in Indian patients: Evaluation of an interventional strategy
D Behera, S Kaur, D Gupta, SK Verma
January-March 2006, 23(1):3-7
In order to improve the self care abilities of the patients with bronchial asthma a 'Self Care Manual' (a Booklet of 26 pages) on bronchial asthma was prepared. An interview schedule was developed to evaluate the usefulness of the manual. The validity and reliability of both these instruments were established. Five hundred and twenty three diagnosed patients of bronchial asthma (260 in the study group to whom the self care manual was given and 263 controls to whom no specific instructions were given) were included in the study. Emotions like 'tension', 'excessive laughter', 'sadness', 'happiness' and 'anger' etc. that triggered the symptoms were studied. The effect of self care manual on other emotions (*a total of 8 items) like 'anxiety due to the disease', 'tension of taking medicine' and 'fear of death' etc. was also studied. Both groups were followed up at 2 weeks, 6 months and 1 year while the same interview schedule was administered on each visit. It was observed that the emotion scores decreased significantly in both the groups (8.08±5.5, 5.89±4.88, 1.44±4.63 and 1.19±4.01 in the study patients, whereas 8.50±6.30, 7.88±6.21, 7.35±6.03 and 5.97±5.81 in the controls) at 0 weeks, 2 weeks, 6 months and 1 year respectively. The emotion scores were significantly less in the study group as compared to controls (unpaired 't' = 3.57, 8.52 and 7.67) at 2 weeks, 6 months and 1 year respectively (p<0.001) Multiple logistic regression analysis showed that the odds ratio of study group patients showing significant improvement in emotion scores was 3.34 (95% CI, 1.78-6.25) and 4.26 (95% CI, 2.34-7.63) at 6 months and 1 year respectively as compared to controls. We concluded that patient education (self care manual in the form of a booklet) made significant improvement in the emotions in patients with bronchial asthma.
Effect of prednisolone on lung function and bronchodilator responses in stable COPD
SK Chhabra, M Ailawadhi
January-March 2006, 23(1):8-14
The effect of a short course of prednisolone on lung function and bronchodilator responsiveness in COPD is debatable.
: After baseline spirometry and measurement of response to inhaled salbutamol, 31 patients with COPD were randomized to the steroid group (given 40 mg/day prednisolone for 7 days) while 29 patients were assigned to the control group. All the patients continued on their usual medication based on published management guidelines. The lung function and response to salbutamol were reassessed on day 8.
and FVC increased after salbutamol to the same extent in both the groups on the two test days. The proportions of FEV
and FVC responders were also similar in the two groups. The bronchodilator response was not reproducible and several responders of day I became non-responders on day 8 and vice versa in both the groups. At the end of 1 week, the prebronchodilator lung function showed similar improvement in FEV
and FVC in the two groups. A multiple logistic regression procedure failed to identify factors that could predict a steroid response.
A short course of prednisolone does not favourably affect lung function and bronchodilator responsiveness in stable COPD.
POINTS TO PONDER
Changing clinical concepts
January-March 2006, 23(1):45-45
COPD etiopathogenesis: Interplay of environmental and genetic factors
January-March 2006, 23(1):15-19
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