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Official publication of Indian Chest Society
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2009| July-September | Volume 26 | Issue 3
Online since
July 6, 2009
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ORIGINAL ARTICLES
A study of skin sensitivity to various allergens by skin prick test in patients of nasobronchial allergy
R Prasad, SK Verma, R Dua, S Kant, R.A.S Kushwaha, SP Agarwal
July-September 2009, 26(3):70-73
DOI
:10.4103/0970-2113.53228
PMID
:20442839
Objective:
To study skin sensitivity to various allergens in patients of nasobronchial allergy.
Materials and Methods:
2880 skin prick tests with 60 allergens were performed in 48 patients of nasobronchial allergy.
Results:
Most common offending allergens were insects (21.2%), followed by dusts (12.0%), pollens (7.8%), animal dander (3.1%), and fungi (1.3%). The common insect antigen were locust female (33.3%) followed by locust male (25%), grasshopper (20.8%), cricket (16.7%), cockroach female (16.7%) and cockroach male (14.6%). Common dust allergens were house dust, wheat dust, cotton mill and paper dust. Among pollens,
Amaranthus spinosus, Argemone mexicana, Adhatoda vasica, Ailanthus
and
Cannabis
were found to be common allergens. In animal danders common offending allergens were cow dander and dog dander. Among fungi
Aspergillus fumigatus, Aspergillus flavus, Alternaria teneis
and
Fusarium sodani
were common allergens. Patients of bronchial asthma had associated allergic rhinitis in 80% cases.
Conclusion:
Common allergens in patients of nasobronchial allergy were identified. The data may prove useful in of allergen avoidance and immunotherapy in these patients.
[ABSTRACT]
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The role of long-term doxycycline in patients of idiopathic pulmonaryfibrosis: The results of an open prospective trial
Parthasarathi Bhattacharyya, Saikat Nag, Sujan Bardhan, Dipabali Acharya, Rantu Paul, Rana Dey, Malabika Ghosh, Ratna Dey, Indranil Saha
July-September 2009, 26(3):81-85
DOI
:10.4103/0970-2113.53231
PMID
:20442842
Objective:
To evaluate the effect of long term use of doxycycline in IPF patients.
Materials and Methods:
Patients of IPF, selected randomly from out patient services and diagnosed on the basis of HRCT chest, were put on doxycycline in an open prospective trial. They were followed up with monitoring of subjective well being along with measurement of pulse rate and arterial oxygen saturation at rest and after a fixed and certain exercise, forced vital capacity, six minutes walk test, St Georges Respiratory questionnaire, and serial chest X-rays.
Results:
Out of seven patients put on doxycycline, six of them continued the drug for a mean period of 531.43 (± 328.88 days). All the patients tolerated the drug well and had shown uniform subjective and overall objective improvement in all the parameters concerned; the change in the radiological parameter being statistically significant.
Conclusion:
Doxycycline merits an appropriate clinical trial in the management of idiopathic pulmonary fibrosis. This widely used and relatively safe drug can add a new dimension to the therapeutic regimen. However, further in-depth studies will be required to evaluate its role in the management of IPF.
[ABSTRACT]
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625
Clinico-pathological profile of lung cancer in Uttarakhand
Jagdish Rawat, Girish Sindhwani, Dushyant Gaur, Ruchi Dua, Sunil Saini
July-September 2009, 26(3):74-76
DOI
:10.4103/0970-2113.53229
PMID
:20442840
Background:
Lung cancer is one of the most aggressive and prevalent type of malignancy causing high morbidity and mortality. Tobacco smoking continues to be the leading cause of lung cancer worldwide. An increasing incidence of lung cancer has been observed in India.
Objective:
The aim of this study was to evaluate the clinico, a pathological profile of the lung cancer in hilly state of Uttrakhand.
Materials and Methods:
We performed a retrospective analysis of histopathologically proven cases of bronchogenic carcinoma admitted in our hospital from January 1998 to August 2005.
Results:
Our study included 203 patients with confirmed cases of lung cancer. Male to female ratio was 8.2:1. The common age group being 40-60 years, 9.86% of the patients were less than 40 years old age. Smoking was found to be the main risk factor in 81.77% patients. The most frequent symptom was cough (72.90%) followed by fever (58.12%). The most common radiological presentation was mess lesion (46.31%). The most common histopathological type was squamous cell carcinoma (SCC) (44.83%) followed by adenocarcinoma (19.78%) and small cell lung carcinoma (SCLC) (16.75%). The majority patients (73.29%) were diagnosed in the later stages of the disease (III B and IV).
Conclusion:
It was found out that SCC was the most frequent histopathological form. SCLC predominates below 40 year and SCC over 60 years of age. Smoking still remains the major risk factors in pathogenesis of lung cancer.
[ABSTRACT]
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Validation of a structured questionnaire for COPD and prevalence of COPD in rural area of Mysore: A pilot study
PA Mahesh, BS Jayaraj, ST Prahlad, SK Chaya, AK Prabhakar, AN Agarwal, SK Jindal
July-September 2009, 26(3):63-69
DOI
:10.4103/0970-2113.53226
PMID
:20442838
Background:
The prevalence of chronic obstructive pulmonary disease (COPD) is increasing in India and there is a need to study the prevalence of COPD, particularly in the rural areas, which may be most affected due to their lifestyle.
Materials and Methods:
First stage: Validation of the questionnaire-105 consecutive patients underwent administration of the structured questionnaire and spirometry was used as a gold standard for the diagnosis of COPD. Second stage: Adults above 40 years (n = 900) in two villages of Mysore district were administered with the validated questionnaire, Knowledge and Attitude questionnaire and Fagerstorm questionnaire, to assess nicotine dependency.
Results:
The questionnaire was found to have a sensitivity of 62.5% and specificity of 87.6% to diagnose COPD. Of the total 900 adults surveyed (Males: 453, Females: 447), the total prevalence of COPD was 7.1%. Males had a higher prevalence (11.1%) compared to females (4.5%). The prevalence of smoking was very high among men at 71.9% and all the women were nonsmokers. The prevalence of COPD was 14.7% in smokers, 19.3% had mild to moderate nicotine dependency and 12.8% were highly dependent. Of the women exposed to regular biomass fuels, the prevalence of COPD was 3.9%, which increased to 4.8% on addition of regular passive smoking. In smoking, male gender and age were significantly associated with COPD (
P
< 0.05).
Conclusion:
The structured questionnaire is a useful tool for the screening of COPD in field studies. Smoking and biomass fuel exposure are important risk factors for COPD.
[ABSTRACT]
[FULL TEXT]
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Alkaline phosphatase: Distinguishing between tuberculous and nontuberculous pleural effusion
Ashish Anantrao Jadhav, Jayashree Suhas Bardapurkar, Anuradha Jain
July-September 2009, 26(3):77-80
DOI
:10.4103/0970-2113.53230
PMID
:20442841
Objectives:
To evaluate the value of pleural fluid alkaline phosphatase and pleural fluid/serum alkaline phosphatase ratio for the purpose of differentiating tuberculous from nontuberculous pleural effusion.
Materials and Methods:
A total of 60 indoor patients, admitted to our hospital, having pleural effusion and suffering from varying etiologies, were included in this study. According to the final diagnosis, these 60 patients were divided into two groups: Tuberculous (30) and nontuberculous (30) pleural effusion.
Results:
The mean pleural alkaline phosphatase and pleural fluid/serum alkaline phosphatase ratio was significantly higher in tuberculous compared to nontuberculous pleural effusion. (
P
< 0.0001). In receiver operating characteristic curve analysis, sensitivity and specificity values were 90% and 80% for a cut-off value of 71 IU/L for pleural alkaline phosphatase activity; and were 90% and 86.66% for a cut-off value of 0.51 for pleural fluid/serum alkaline phosphatase ratio.
Conclusion:
From this study it is concluded that alkaline phosphatase activity remains a useful test in differentiation of tuberculous from nontuberculous pleural effusion.
[ABSTRACT]
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[PubMed]
3
3,673
798
CASE REPORTS
Bloom syndrome with lung involvement
Girija Nair, Ivona Lobo, TK Jayalaksmi, Abhay Uppe, Savita Jindal, Abhishek Chandra, Shivani Swami
July-September 2009, 26(3):92-94
DOI
:10.4103/0970-2113.53234
PMID
:20442845
We report a case of a 24-year old male presented with cough and breathlessness with diabetes mellitus and diagnosed as a case of bloom syndrome. He was a product of consanguineous marriage, having short stature, dolicocephaly, polydactyly, prominent nose with telangiectasia face. The respiratory system examination revealed bilateral coarse crepitations and wheezes and the chest X-ray revealed emphysema with right middle zone inhomogenous opacity. Also, CT thorax examination revealed bilateral cystic bronchiectasis with bronchiolitis obliterans. Bloom's syndrome was diagnosed on the basis of clinical features.
[ABSTRACT]
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[CITATIONS]
[PubMed]
2
2,445
390
Progressive increase in cavitation with the evolution of fungus ball: A clue to the diagnosis of chronic necrotizing pulmonary aspergillosis
R Prasad, Sanjay R Garg
July-September 2009, 26(3):95-97
DOI
:10.4103/0970-2113.53235
PMID
:20442846
Chronic necrotizing pulmonary aspergillosis (CNPA) is an uncommon pulmonary infection seen in the patients with chronic obstructive pulmonary disease, bronchiectasis, pneumoconiosis, diabetes mellitus, alcoholism, poor nutrition or low dose corticosteroid therapy. Here, we are presenting a case of CNPA with diabetes mellitus that was misdiagnosed as pulmonary tuberculosis.
[ABSTRACT]
[FULL TEXT]
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[PubMed]
2
2,038
444
Primitive neuro-ectodermal tumor of the lung in an adult
GS Gaude, PR Malur, R Kangale, S Anurshetru
July-September 2009, 26(3):89-91
DOI
:10.4103/0970-2113.53233
PMID
:20442844
A rare case of a thoracic primitive neuro-ectodermal tumor in an adult is presented here. In this case, wide excision surgical excision followed by chemotherapy and radiotherapy were delivered. But due to the rapid aggressive progression of the tumor, which is the characteristic of disease, the patient died within four months after the diagnosis.
[ABSTRACT]
[FULL TEXT]
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[CITATIONS]
[PubMed]
1
1,885
356
VIEWPOINT
Diagnostic criteria of tuberculous sarcoidosis
JR Shah, Jagruti Hede, RS Mathur
July-September 2009, 26(3):86-88
DOI
:10.4103/0970-2113.53232
PMID
:20442843
With the object to strengthen the clinical status of tuberculous sarcoidosis, we present in this article, the case records published in internationally recognized journals by specialists. From review of clinical material, we have also formulated a table that defines diagnostic criteria of tuberculous sarcoidosis.
[ABSTRACT]
[FULL TEXT]
[PDF]
[CITATIONS]
[PubMed]
1
2,974
676
EDITORIAL
Tuberculous sarcoidosis: Is it a separate entity?
Ritesh Agarwal, Dheeraj Gupta
July-September 2009, 26(3):61-62
DOI
:10.4103/0970-2113.53225
PMID
:20442837
[FULL TEXT]
[PDF]
[PubMed]
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3,212
739
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